IN VITRO TOXICITY TESTS

One of the reasons a molecule with potential therapeutic properties does not pass the next stage of research is because of its toxic effect on cells. Identifying the potential toxicity of a new molecule early in product development will help save time and money for further research.

Advantages of performing in vitro toxicity tests:

  • provide the necessary information on cellular and molecular processes,
  • the possibility of carrying out the test for many compounds at the same time under the same conditions, which allows to obtain reliable and comparable results,
  • the ability to determine the effect of the tested molecule on cell proliferation and its kinetics,
  • the possibility of preliminary determination of the safety of a medicinal product,
  • reducing the risk of introducing potential therapeutic agents into the clinical trial phase, which would cause adverse side effects on the functioning of the body,
  • time saving - elimination of toxic molecules at an early stage of product development.

Hepatotoxicity tests

Hepatotoxicity is the most common reason for the withdrawal of a compound with therapeutic properties in the late stage of product development (statistical studies show that this applies to approx. 30% of the withdrawn compounds). In our offer you will find a service in the field of testing the effect of compounds on liver cells – hepatocytes. These cells were derived by differentiating human induced pluripotent stem cells (hiPSc).

Neurotoxicity tests

Nerve tissue is made up of cells that are highly sensitive to the toxic effects of substances. Therefore, a very important element of researching a new compound with therapeutic potential is studying its effect on nerve cells.
For this purpose, Celther Polska has developed a neurotoxicity test based on the use of human induced neural stem cells (iNSc) derived from hiPSc.

Cardiotoxicity tests

The cardiotoxicity tests offered by our team are based on the study of the effect of the compound on human induced cardiomyocytes differentiated from hiPSc. These cells are especially designed to support research into a new drug, to test its effectiveness and level of toxicity. Thanks to this, at an early stage of development of a product with therapeutic potential, it is possible to eliminate molecules that have shown toxic properties on cells from further research, and thus save time and resources in further research.

Cytotoxicity tests performed on human primary tumor cell lines

We offer cytotoxicity tests of various compounds on neoplastic cell lines, which enables the assessment of their anti-cancer properties. Additionally, we also conduct cytotoxicity testing on normal cell lines.

We adapt each research offer to the client’s needs. We individually define the concentration range, the number of time points and the number of repetitions.